The glass reactor is placed in a closed glass reactor under constant temperature conditions. The stirring reaction can be carried out under normal or negative pressure conditions according to the application requirements, and the reaction solution can be refluxed and distilled. Currently, it is a modern fine chemical and biopharmaceutical. Ideal for synthesizing new materials. With the development of technology and the expanding demand of bio-pharmaceutical industries, the development of glass reactors is accelerating, and the types and functions of products are increasing and the applications are becoming more widespread.

 

It is well known that proper installation and proper operation of the equipment are prerequisites for ensuring stable operation of the glass reactor. According to the industry, in the process of working in a double-layer glass reactor, in fact, some places are very easy to be ignored by users. In this regard, the industry has made a summary based on experience, and the author has carried out a brief arrangement.

S-50L Jaketed glass reactor

 

1. Pay attention to insulation. It is understood that the insulation performance is poor due to the small thickness of the interlayer in the middle of the glass reactor. In the process of using high temperature and low temperature, users need to use insulation material to protect the kettle body.

At the same time, the user needs to wrap the kettle body and the liquid-conducting tube of the reaction kettle with insulation material, pay attention to the thickness of the insulation layer to ensure better insulation effect.

 

2. Temperature control medium selection. In general, the user will select different temperature control media according to the required reaction temperature as the heat transfer medium for the reaction. Choose bath at low temperature, choose water bath at normal temperature, and choose oil bath at high temperature.

It is recommended in the industry that when using low temperature or high temperature, pay attention to the choice of suitable medium, the key is viscosity. "The viscosity is too large, the circulation pump may not move, the medium circulation effect is not good, and the required temperature control effect cannot be achieved. The high-power circulating pump is rushed to change, the pressure of the pressing medium is too large, and the double-layer glass reactor is easily damaged. Lining, the reactor is broken."

It is understood that manufacturers usually choose the appropriate heating medium according to their own products.

 

3. The storage location needs to be reasonable. The single-layer glass reactor is used as a reaction amplification test device, and the volume is usually 50 - 150L. The volume of the specific case can be customized. Therefore, the scale of the test should not be underestimated. Since the kettle body is made of glass, stainless steel is the bracket and the legs are casters, the storage position needs to be carefully selected.

As far as the storage conditions are concerned, although the casters can be fixed with a foot buckle, the stability is not strong. Therefore, the user pays attention to selecting a flat place to lay flat during the storage process, and keeps the mechanical stirring center consistent with the reaction kettle, otherwise it is easy to shake and unstable, and a safety accident occurs. In addition, it must be placed in a well ventilated location.

F-50L Single layer glass reactor

4. Precautions for feeding. Since the jacketed glass reactor is an independent reaction rack and the reserved feed port is small, the feeding process is difficult.

In this regard, it is recommended in the industry that solid reagents can be formulated into a solution, and liquid reagents can be pumped into the kettle through a matching water pump or oil pump. In particular, the reaction material is added to the reaction vessel through a constant pressure dropping funnel or a common dropping funnel, and a corresponding moving ladder is required to allow the worker to add the test material.

In addition, the one-time feeding amount of the glass reactor should not be too large, and the user needs to evaluate according to the temperature, reflux and pressure of the reaction, and the appropriate amount of the material to be added is generally not more than 2/3 of the body.